In the 60's, the Puerto Rican Carlito Brigante, the Afro-American Earl and the Italian Rocco become best friends while in prison. When they are released, Rocco intermediates a heroin business with a family of the Italian Mafia leaded by Artie Badalato Sr. Carlito negotiates with the lord Leroy "Hollywood Nicky" Barnes the area where the trio could operate in his neighborhood and sooner the three friends become powerful. Later, Carlito dates and has an affair with the beautiful Leticia. When Earl decides to move to Barbados with his girlfriend and leave the heroin business, his stupid younger brother causes a situation with the Italian mobsters, and Carlito and Rocco have to resolve the mess to save their lives.

The rise and fall of salsa singer, Héctor Lavoe (1946-1993), as told from the perspective of his wife Puchi, who looks back from 2002. In the early 1960s, Héctor arrives in New York from Ponce, Puerto Rico. Success comes quickly. "The more he grew as an artist," Puchi says, "the more he sank as a person." It's a tale of talent - creating salsa with Willie Colón, with the Fania All Stars, and as a soloist - and a story of disintegration - fueled by drugs, alcohol, partying, and depression. Puchi's voice - proud and querulous - dominates off-stage as Héctor's does on.